Neoadjuvant endocrine therapy for luminal breast cancer treatment: a first-choice alternative in times of crisis such as the COVID-19 pandemic

The epidemiological emergency caused by CoV-2 (COVID-19) has changed priorities in breast cancer management. In those places where the pandemic has had the greatest effect, it is of paramount importance for most patients to be at home, reducing or postponing their attendance at clinics, as well as avoiding surgeries. In this scenario, neoadjuvant endocrine treatment could be an appropriate alternative treatment for hormone receptor positive breast cancer (luminal-like tumours) in order to minimise hospital admissions and to delay elective surgeries. Accordingly, we present a simple protocol that can be applied to most cases of luminal-like breast cancer and is appropriate for the majority of secondary or tertiary medical centres, or even primary car

DETERMINANTS OF PRIVATE EQUITY FUNDRAISING IN WESTERN EUROPE

The aim of this paper is to identify the key factors that lie behind venture capital/private equity fundraising in countries where there is scarce and asymmetric information about final returns. The main contribution of this paper is to explain fundraising by means of variables directly related to the venture capital process rather than by macroeconomic ones. We use panel data techniques on data from 16 European countries during the nineties. In the light of the long period required for investing committed capital and the illiquid nature of investments until the fund is divested, the focus is placed on the investing capabilities of fund managers. We find that the amounts invested in the previous year have a positive and significant impact on fundraising. In this sense, the market would be regarding the ability of fund managers to invest the total amounts investors have previously committed.Disbursements; Fundraising; Private Equity; Venture Capital.

CHARACTERISATION OF THE REPUTATION OF PRIVATE EQUITY MANAGERS: EVIDENCE IN SPAIN

In the light of the Agency and Signalling Theories, the aim of this paper is to analyse the relationship between investors and private equity managers in order to identify the factors that affect the latter's reputation. Since there are no individual references about their past returns, the reputation of such players is thought to be linked to their capacity for obtaining new funds in countries such as Spain. Two groups of variables that might affect reputation are identified: variables in the first group are linked to the private equity cycle, and those in the second are related to the external image of the operator. The analysis focuses on the activity of almost all private equity investors operating in Spain during 1991-2001. The results show that the lagged volume of investments acts as an indicator of the ability to manage larger amounts of capital. The exogenous characteristics of highest importance are the size of the funds under management and the belonging to the National Private Equity Association. Because of the wide variety of private equity firms, the analysis is completed for diverse groups, which may behave in a different manner. En este artículo se analiza la relación que se origina entre inversores y operadores decapital riesgo dentro del marco de las Teorías de Agencia y de Señales. La finalidad esidentificar los factores que determinan la reputación de estos operadores. Ante la ausenciade referencias individuales de rentabilidad, la reputación puede representar un elementobásico para señalar la capacidad para captar nuevos fondos en países en los que el mercadode capital riesgo está en proceso de maduración. Dos grupos de variables que puedenafectar a la reputación son identificados: uno relacionado con la actividad desarrolladay otro vinculado a aspectos externos. El análisis se centra en la actividad de la prácticatotalidad de operadores de capital riesgo activos en España durante el periodo 1991-2001.Los resultados muestran que el volumen de inversiones registrado en el pasado indica unacapacidad para gestionar una cifra superior de capitales. Las características exógenasde mayor importancia son el tamaño del operador y la pertenencia a la AsociaciónNacional de Capital Riesgo. Dada la gran variedad de operadores existentes en España,el análisis se completa para diferentes subgrupos que podrían comportarse de distintamanera, encontrándose evidencia en este sentido.Captación de fondos, capital riesgo, reputación; Teoría de Agencia y de Señales. Fundraising, private equity, reputation; agency, signalling theory.

Magnetized, Relativistic Jets

Extragalactic relativistic jets are composed by charged particles and magnetic fields, as inferred from the synchrotron emission that we receive from them. The Larmor radii of the particles propagating along the magnetic field are much smaller than the scales of the problem, providing the necessary coherence to the system to treat is as a flow. We can thus study them using relativistic magnetohydrodynamics. As a first step, we have studied the structure of steady-state configurations of jets by using numerical simulations. We have used a helical field configuration and have changed different relevant parameters that control the way in which the energy flux is distributed in jets (namely, the proportion of the energy flux carried by internal, kinetic or magnetic energy). Our results show significant differences among the different kinds of jets. Finally, we also report on results based on synthetic maps of our simulated jets.Comment: Submitted for publication in Proceedings of Science, as contribution to the proceedings of the XII Multifrequency Behaviour of High Energy Cosmic Sources Workshop, held in Palermo, 12-17 June 201

Catalonia in deadlock, and why that is a European problem

The Catalan territorial conflict is stuck. No clear solutions are on the table after the elections of December 21st. Catalans and Spaniards are failing so far to find solutions to the problem. But it is our European common problem and our common responsibility to try to help them. More specifically, EU institutions should be doing much more of what they have done so far. I blame them for their passivity in the last couple of months